The track also debuts on the Streaming Songs chart.
Lizzo scores her first entry on the Billboard Hot 100, as "Truth Hurts" debuts at No. 50 on the chart dated May 18.
The song by the rapper/singer opens with 13.6 million U.S. streams, up 33%, in the week ending May 9, according to Nielsen Music, as the sum drives the bulk of its Hot 100 standing. The total also sparks the track's No. 28 debut on Streaming Songs, where it's likewise her first charted title.
"Hurts" additionally sold 8,000 downloads in the tracking week.
Lizzo originally released the song, which she wrote with Ricky Reed, Jesse Saint John and Steven Cheung, in September 2017. However, it has received renewed attention after being featured in the Netflix rom-com Someone Great, which premiered April 19. The song has also been added to Lizzo's new LP Cuz I Love You, which debuted at No. 6 on the Billboard 200 chart dated May 4.
"Hurts" concurrently begins at No. 19 on Hot Rap Songs (marking her first entry on the ranking) and No. 21 on Hot R&B/Hip-Hop Songs.
Meanwhile, "Juice," the lead single off Cuz I Love You, also makes moves, rising 9-8 on Hot R&B Songs, 23-22 on Adult R&B Songs, 33-29 on Pop Songs and 44-41 on Hot R&B/Hip-Hop Songs.